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Sibutramine (Meridia) is a well-known appetite suppressant. It also has a remarkable effect in terms of weight loss and fat burning. It is used along with a proper diet and exercise to treat obesity and unnecessary fat.
Sibutramine hydrochloride is a selective serotonin and noradrenaline reuptake inhibitor used for the medical management of obesity. This pharmaceutical is intended to be an adjunct to a reduced-calorie diet, which will help increase weight loss compared to that achieved with modifying food intake alone. Sibutramine hydrochloride is not advertised as a rapid-acting drug, but instead, one that fosters slow, safe, and steady losses in fat mass which are maintained long-term.
Sibutramine hydrochloride exerts a weight-loss effect through two distinct mechanisms. It has a marked ability to suppress appetite. During some studies, patients would reduce their daily energy intake by as much as 1,300 calories while taking this drug.1 In addition to its effects on caloric intake, sibutramine also stimulates metabolism and daily caloric expenditure. A single 10 mg dose has been demonstrated to increase the basal metabolic rate by up to 30%, an effect that is maintained for at least six hours. This thermogenic action is known to occur via the adrenergic system, mainly through the indirect support of beta 3 receptor activation. With the use of this drug, we are specifically seeing a strong increase in brown adipose tissue thermogenesis (BAT), which is accompanied by body temperature increases of .5 – 1 degree Celsius.2 Elevated body temperature is a good indicator that thermogenesis is being triggered, which you may recall as one of the key things we are looking for when taking clenbuterol.
To get a better idea of exactly how well sibutramine hydrochloride works, we refer to some of the clinical studies on this agent. One investigation was conducted at the Kansas Foundation for Clinical Pharmacology in 2001. Here, a group of 322 obese patients were given either 20 mg of sibutramine or placebo once daily for 24 weeks. By the conclusion of this study, 42% of patients in the sibutramine group lost 5% or more of their initial body weight, while 12% noticed a 10% or greater loss in body weight. Sibutramine was also associated with significant improvements in serum triglyceride and HDL cholesterol levels, which were displaying poor values at the onset of the study. Another detailed investigation was completed in China by the Department of Endocrinology for Rui-jin Hospital this same year and involved giving only 10 mg per day of sibutramine to a group of 120 men and women.3 This investigation also faired extremely well, with patients losing an average of 15 pounds by the 24th week of use.